1. What do the statistics indicate on CRC cancer?
CRC is the third most frequent cancer in Argentina after breast cancer and prostate cancer. According the IARC (International Research Agency of Cancer- WHO) indicators in the country, 11000 new cases have arisen in 2008 of which 5800 of them were men and 5200 women.
2. Which are the risk factors of CRC?
The risk of having CRC increases when people get old. More than 90% of cases correspond to individuals of more than 50 years old.
Besides age, there are other risk factors that should be considered:
3. Which are the treatments of CRC?
Depending on the localization and CRC stage, currently available treatments are the following:
- Aimed therapies (example.Anti- EGFR therapy)
Mutational stage of Biomarkers Kras/Nras in the 2, 3 and 4 exons must be determined in all metastatic CRC patients with the administration of an anti-EGFR therapy because this therapy must only be administrated when there are no mutations in those genes.
Stintzing, S. Phase III FIRE-3 trial data show most patients with wild-type RAS metastatic colorectal cancer benefit from first-line FOLFIRI plus cetuximab treatment. Amsterdam: ESMO @ ECC; 2013..