Gastrointestinal Stromal Tumors Studies

Gastrointestinal Stromal Tumors Studies 2017-08-29T16:10:54+00:00

GASTROINTESTINAL STROMAL TUMORS (GIST) STUDY Download files

gastrointestinalGastrointestinal stromal tumors (GIST for its acronym in English) are the most common mesenchymal neoplasm in the gastrointestinal tract, and perhaps the most common sarcoma of all. They originate from the interstitial cells of Cajal or their precursors, these cells have characteristics of smooth muscle cells, fibroblasts and neurons. GIST’s are typically positive for the KIT tyrosine receptor by immunohistochemistry. At the genomic level, mutations in the KIT gene or in the gene receptor tyrosine kinase PDGFR are the characteristics that distinguish this type of tumor. KIT and PDGFRα are mutated in approximately 85% and 5% respectively.

Biomaker Evidence Type Molecular Alteration
Therapeutic Implication
Analysis Methodology*
Test ID
C-KIT Recomended Predictive Mutations Sensitivity to Tyrosine Kinase Inhibitors (Imatinib) S. Sanger GiCKsa
PDGFR-α Recomended Predictive Mutations Sensitivity to Tyrosine Kinase Inhibitors (Imatinib) S. Sanger GiPGsa
BRAF Recomended Prognostic and Predictive Mutations Increased risk of malignancy. Sensitivity to Tyrosine Kinase Inhibitor (Imatinib) S. Sanger GiBRsa

 

*S. Sanger: Sanger Sequensing

1. What are the treatments for gastrointestinal stromal tumor?

  • Surgery
  • Targeted therapy: imatinib mesylate in unresectable tumors, to shrink the tumor, followed by surgery to remove as much of the tumor as possible. In GIST’s that are metastatic or that recur it is used imatinib mesylate, if the tumor begins to grow as they administer therapy with imatinib mesylate or if the side effects are very bad.

This section presents a classification of molecular studies currently available. This website information has been supervised by our BIOMAKERS specialists’ team. The recommendations present here do not aim to substitute the guidelines of medical societies or the oncological treatment guidelines currently available.

Consulted Sources:

National Institute of Cancer
Center for Control and Prevention of Diseases
PUBMED
American Cancer Society
My Cancer Genome

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Cáncer de Pulmón
Cáncer Colorrectal
Cáncer de Mama y Ovarios
Cáncer de Tiroides
Cáncer Melanoma
Tumores Sistema Nervioso
Leucemia Mieloide
Linfoma y Mieloma
Estroma Gastrointestinal
Tumores Hereditarios
Toxicidad y Metabolismo
Paneles Tumorales
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